International_Bet_91 t1_jegcumi wrote
Reply to comment by barbzilla1 in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn
This is wrong.
Acetaminophen is a level 1 (weak) analgesic. Opioids are level 2 or the 3 depending on the drug. Level 3 is the highest level.
barbzilla1 t1_jeglpd2 wrote
When they are speaking of pain meds here they are testing responsiveness to said pain using the hotplate test with mice. While it has an analgesic property as it brings relief, it is not lessening nerve signals as the topic was about. I realize I'm using layman's terminology, but there are many plants with much better allergies and effects as far as reducing nerve signal. Such as Tylenol and aspirin, so honestly the gold standard is cone snail toxin but most people are prescribed either gabapentin or Lyrica.
AAA515 t1_jegvr3u wrote
What is this hotplate test and why do I not like it already?
barbzilla1 t1_jeh2h6l wrote
They set the temperature of a scientific hotplate to the level painful but not physically damaging to lab mice, then administer a combo of whatever drug they are testing and a control/placebo to various mice, they then place said mice in said hotplate and time the pain reaction. The mice usually get used for between a week and a month then are either dissected or disposed of.
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