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almostbig t1_j4zzqxb wrote

/u/fruticosa explained here how genes end up being duplicated and suffer mutations throughout a timeline.Ricin comes from a unfortunate chain of events driven solely by evolutionary pressure and the randomness of nature.

The A chain of the protein, the one which inhibits the ribossomes, which causes it to effectively be toxic. It, among other similar ribossome-inhibiting proteins, has originated from a presumably defense-related protein that existed in an early angiosperm species.

It underwent it's own mutations over the ages, ended up being, in some of the higher plants, a gene that is duplicated several times and expressed differently in multiple phases of plant development, remember, not necessarily that means it has any function.

In some, however, it ended up becoming associated with another chain, the B chain. The B chain itself has originated from simple sugar-binding proteins, which basically any living being has in it's cytoplasm. Through the odds and evolutionary pressure, it ended up turning into a galactoside-binding chain.

That B chain, associated with A chain, is what is up with ricin. The galactoside-binding chain, once in our bodies, will bind with cell surface sugars, which therefore leads the cell to take the whole protein inside via endocytosis. Ribossomes are key parts of protein synthesis, their disruption by the A chain will lead to death in eukaryotic cells.

basically, two early proteins that were not really related at all went through numerous mutations, "fused" and originated it. At later evolutionary points, the dimer gene itself went through duplications and more modifications, coding for toxin-like proteins we see in some plants, but that's not the point.

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DaylightsStories t1_j4veoey wrote

To poison things. Castor seeds are relatively large and would be a good source of food so there is strong pressure in favor of the plants who have seeds that are fatal to chew up and swallow. I cannot think of anything that ricin does that the plant would benefit from except for saving the lives of other seeds by killing whatever ate the first few.

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GalFisk OP t1_j4za39o wrote

Thanks. I'm curious as to how it did evolve, and what it was before it became such a deadly toxin. But all research i can find has gone into what it does to humans and animals.

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DaylightsStories t1_j4zxl2r wrote

I suspect it was probably a less deadly toxin beforehand(given that the family castor is in, Euphorbiaceae, are notoriously likely to be poisonous) although the subject of plant evolution in general is poorly studied and I would not be surprised if this has never been looked into.

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almostbig t1_j500s6z wrote

it has, but not really surprisingly the answer is:
1 - plant make protein for defense

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2 - plant happy

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3 - Florida or whatever happens randomly

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4 - Ricin

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