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phatspatt t1_j9t24ud wrote

they cut off their regression 99 days post vaccination, i dont think they say why other than vsccine effects "wane with time"

they also were not powered to look at moderate or mild symptoms due to confounders.

"Bivalent boosters provided substantial additional protection against severe omicron infection in persons who had previously been vaccinated or boosted, although the effectiveness waned over time. The effectiveness of bivalent boosters was higher than that of monovalent boosters."

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FartOfGenius t1_j9teob6 wrote

I think the 99 days was just to provide the same amount of time for comparison between the monovalent and bivalent cohorts

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TheThirdDumpling t1_j9um7bn wrote

60% against death? wow, I mean, its not bad, but that is much lower than I expected.

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Sanpaku t1_j9uzzrd wrote

Omicron has tricks up its sleeve to evade either vaccine or naturally acquired immunity, and Paxlovid markedly improved survival rates, so that vaccine acquired immunity plays a lesser relative role in survival. 62% is no 92%, as earlier in the pandemic, but its better than nothing.

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Don_Ford t1_j9xq5tf wrote

The mRNA was never good in any capacity.

If the risk of death from COVID is your primary concern then you are going to have a bad time with Long COVID.

Novavax is the far superior vaccine.

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AaronfromKY t1_j9u3xw9 wrote

Anecdotally, my fiancee and I contracted covid at the end of January. She had much worse symptoms than I did, coughing fits and chills and lethargy, while I had a cough here or there, some fever and only a mild lethargy. The difference between us was I had the bivalent booster and she hadn't.

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Alternative-Flan2869 t1_j9xg3q6 wrote

Not surprised - my recent bout of covid was less of an issue than a common cold.

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Don_Ford t1_j9xq8ur wrote

To bad the mechanics of the virus are completely different and your immune response is a terrible way to relate risk. COVID is a syncytia SARS virus that eats your body.

But sure... it's a cold... because it's in your upper respiratory tract, next to your brain.

Good one.

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