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Wagamaga OP t1_ir2fjae wrote

COVID-19 vaccination during pregnancy was linked to a lower risk of neonatal intensive care unit (NICU) admission, stillbirth, and maternal SARS-CoV-2 infection and no additional risk of preterm birth, small for gestational age (SGA), low Apgar score, cesarean delivery, postpartum hemorrhage, or chorioamnionitis, finds a systematic review and meta-analysis published yesterday in JAMA Pediatrics.

Japanese researchers led the analysis of nine observational studies comparing the pregnancy outcomes of 81,349 women who received at least one COVID-19 vaccine dose with those of 255,346 unvaccinated peers through Apr 5, 2022. Average age was 32 to 35 years in the vaccinated group and 29.5 to 33 years in the unvaccinated group.

Among vaccinated women, 98.2% had received an mRNA vaccine (Pfizer/BioNTech, Moderna, or unstipulated), while 1.1% received a viral vector vaccine (Oxford/AstraZeneca or Johnson & Johnson), and 0.7% were undocumented.

In the six studies that reported the number of doses, 85.4% of women received two doses of an mRNA vaccine. Seven studies reported the timing of the first dose, with 5.9%, 46.3%, and 47.8% of women receiving their first dose during the first, second, and third trimester, respectively.

https://www.cidrap.umn.edu/news-perspective/2022/10/covid-vaccines-pregnancy-tied-lower-risk-nicu-stay-stillbirth

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[deleted] t1_ir30oq4 wrote

[removed]

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Claritywind-prime t1_ir3edfy wrote

What?

The Covid vaccines are free to all Japanese citizens (Japan being where researchers are) and most non-citizens.

Therefore would that not eliminate bias for higher incomes, post- and pre-natal care affordability, etc?

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Antique-Ad1871 t1_ir3q6x4 wrote

Yeah the comment above you is not real, no idea what the hell they are talking about

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slammaster t1_ir4uiqm wrote

A lot of interesting things in the abstract - I thought the average age being 32-35 across the samples was interesting.

They also can't speak to causality - there's a difference between those that do and don't choose to get vaccinated, and a lot of the variables that influence that decision (education, income, age) are also known to influence pregnancy outcomes. That's probably why they talk about no evidence of increased risk, even though they found a slightly protective effect.

Regardless its a comforting result for people that are currently pregnant - my wife got the vaccine during pregnancy and we did fine, but this SR would have provided some additional comfort to the decision.

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Wiggen4 t1_ir657kk wrote

I have close friends who recently got married. She works as a nurse and there was a lot of tension with her work because she was concerned about fertility and the vaccine. It was a situation that really made me re-evaluate mandatory vaccinations for work. This study (while not necessarily about fertility directly) would have been useful to allay fear

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