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Wild_Garlic t1_ixk19bm wrote

This bodes well for my brain.

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True_Garen OP t1_ixjv3n2 wrote

Garlic, Allium sativum, has long been utilized for a number of medicinal purposes around the world, and its medical benefits have been well documented. The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically. Garlic and garlic extracts, especially aged garlic extracts (AGEs), are rich in bioactive compounds, with potent anti-inflammatory, antioxidant and neuroprotective activities. In light of these effects, garlic and its components have been examined in experimental models of Alzheimer’s disease (AD), the most common form of dementia without therapy, and a growing health concern in aging societies. With the aim of offering an updated overview, this paper reviews the chemical composition, metabolism and bioavailability of garlic bioactive compounds. In addition, it provides an overview of signaling mechanisms triggered by garlic derivatives, with a focus on allicin and AGE, to improve learning and memory.

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bayesian13 t1_ixmaohf wrote

from the conclusions" "The data given in this review highlight the beneficial antioxidant and neuroprotective anti-inflammatory properties of allicin and AGE contained in garlic extracts. However, these studies are derived from cellular or mouse models, while clinical trials concerning these compounds and AD are not present, suggesting that this evidence should be confirmed in human studies before the beneficial effects of compounds contained in garlic might be translated into therapy. Finally, the importance of the NLRP3 inflammasome pathway in neuroinflammation and neurodegenerative diseases, such as AD, has been established [125], and very recent data on its modulation via allicin have been reported, whereas no evidence has been shown for AGE, implying the need for further characterization."

  1. mouse trials only, need human trials  

  2. Aged Garlic Extract may be less effective. stick to the fresh stuff

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True_Garen OP t1_ixmk7kh wrote

>Aged Garlic Extract may be less effective. stick to the fresh stuff

But

https://greyduckgarlic.com/garlic-boosts-learning-and-memory.html

Garlic increases serotonin concentrations in the brain (Haider et al. 2008). High serotonin concentrations are associated with improved brain functions such as learning, memory and mood.

Aged garlic extract inhibits cortical acetylcholinesterase (AchE) while increasing glutathione (GSH) concentrations (Mukherjee and Banerjee 2013). GSH is a potent internal antioxidant that protects brain cells from free radical damage. Some treatments for Alzheimer's disease use AchE inhibition. AchE inhibition may affect executive and attentional cognitive functions (Bohnen et al. 2005).

Ethyl acetate extracts from aged garlic protects nerve cells from Aβ-induced ROS generation in vitro (Jeong et al. 2013).

Aged garlic compounds, in particular S-allyl-L-cysteine, protects neural cells from ROS. Interestingly, pretreatment of cells with garlic extract protected 80% of cells from ROS-mediated damage. It also protected pre-synaptic proteins (Ray et al. 2011). This may be beneficial in treating Alzheimer's Disease (Chauhan and Sandoval 2007, Ray et al. 2011).

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