WoolyLawnsChi t1_jdw392l wrote on March 27, 2023 at 4:55 PM

Reply to comment by BousWakebo in Scientists discover how cancer cells evade immune system by BousWakebo

>the thickness of cancer cells' glycocalyx is one of the major parameters determining immune cell evasion and engineered immune cells work better if the glycocalyx is thinner.
>
>As a result of these findings the researchers then engineered immune cells with special enzymes on their surface to allow them to attach to and interact with the glycocalyx. They then found that these specialized immune cells were able to overcome the glycocalyx armor of cancer cells,

If I am reading this correctly the discovery isn't some new "drug"

instead it will make existing immunotherapies more effective

Phoenix5869 t1_jdw9fnf wrote on March 27, 2023 at 5:35 PM

> it will make existing immunotherapies more effective

That’s good to hear, but it’s a far cry from what the title implies

ConversationOk4414 t1_jdzgzfa wrote on March 28, 2023 at 9:45 AM

They’ve successfully eradicated a form of cancer (I don’t remember which) in their entire study group using this technique.

Solid_Hunter_4188 t1_jdw7gdn wrote on March 27, 2023 at 5:22 PM

Sounds like a selection/gene therapy done specifically to tcell or NK’s to either increase the number of detectors or improve binding of existing MHC

Brain_Tourismo t1_jdyxij3 wrote on March 28, 2023 at 5:15 AM

I thought they had engineered enzymes onto the existing NKs, no? Sure it is an extra step but well worth it.