This is the pessimistic view, there is tons of optimism, but one pessimistic prediction will not hurt.

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• There is covid, it ages the population faster (internal damages similar to aging) we don't know by how much yet, regardless of now, it will mutate until it perfects it, so lifespan will go down to 50? 60? in the next 20 years or so.
• People want the CO2 issue fixed, so we will have less from everything, cars, energy, homes, food, clothing, etc.
• Viruses and Bacteria got suppressed by a 100 years, there are so much chemicals we can mix until they evolve to go around them, so sickness will be more common.
• On the good side will perfect automation of making every day products.