I have never written fan mail to anyone in my almost 40 years of existence: despite absorbing a ton of media, never written a favorite author, director, musician, actor, anyone. Until I read this specific comic (it's from Subnormality by Winston Rowntree), and I wrote him an e-mail letting him know that a lot of his work really resonated and helped me, inspired me, and sometimes just entertained me.

I highly recommend you check out his other stuff, but be forewarned: although he's a webcomic artist, don't expect many three-panel jokes and the like; each one is more like a short play or novella, so you have to strap in.

Edited to add: I actually bought of poster of this and have it on a wall of art I love. It's a nice daily reminder.