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HazMatterhorn t1_itsrm1h wrote

How can I figure out which psychedelics are safe to take with my antidepressant/anti-anxiety medications, and in what amounts?

I’ve gathered some medications dull the effect of psychedelics, some enhance it, and maybe some are potentially deadly? Info online always seems to range from “you will get serotonin syndrome and die” to “if you need psychiatric medication you should not be tripping.” But my friends and I have had enough positive experiences to know that it isn’t categorically dangerous. Where can I get good harm-reduction info about this?

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psychsafetyalliance OP t1_itstchu wrote

There's not enough research on this and not enough of it is centralized, which sucks given that this is a common question.

It's a really complicated thing to try and study given how many psychedelics and psychiatric medications there are.

Here's a table we found about combinations between various psychedelics and antidepressants.

We don't know of anything relevant to contraindications with anti-anxiety meds and many psychedelics, but because ketamine is a legal medicine, you can at least find contraindications between ketamine and various psych meds using the Drugs.com Interaction Checker.

There's some research you can do on Google by typing "__name of psychedelic___" and "__name of psychiatric medication__", then adding the words "interaction," "combination" and "contraindications" to that in three successive searches. Much of what you'll find through this method is not medical research and thus should be treated as for informational purposes only.

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psychsafetyalliance OP t1_itstlja wrote

If you know anyone with a lot of money who'd like to fund a psychedelic safety organization to wrangle a bunch of experts to do a literature review on this topic and compile an at-a-glance resource for folks with this question, we might know some people they'd want to talk to. ;)

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psychsafetyalliance OP t1_itsxrh2 wrote

One category of psychiatric medication that's contraindicated with a ton of other drugs is the MAOI's, which one could argue might fit under the "categorically dangerous" header.

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