Easy: Buy some sketchy black market drugs from an untrained person you don't know, don't test them, take a large, unmeasured dose in a chaotic environment with people you feel unsafe with, throw a bunch of other drugs in the mix without checking for potential interactions, and see what happens!

Just kidding. We've seen people do all those things and it rarely goes well.

We made a masterclass to answer this question. It covers all the skills and awareness you need to have if you plan to take psychedelics outside of a supervised medical, therapeutic, or ritual environment and want be as safe as possible.

We still don't recommend that anyone take psychedelics without professional supervision, but if you're gonna do it anyways, you might as well know all the ways people accidentally fuck themselves up so you can avoid same.