DrJosephDavisDO OP t1_iwxnynk wrote
Reply to comment by imposter_syndrome1 in I'm Dr Joseph Davis, Medical Director at Cayman Fertility Center. AMA about fertility, reproduction or IVF treatment. by DrJosephDavisDO
Great question. OHSS does get worse shortly after trigger especially with an hCG trigger (vs an agonist trigger). The symptoms peak as you rightly said 3-7 days after trigger. The benefit of freezing embryo rather than fresh transfer is the reduce the severity of the OHSS while it resolves. I typically use agonist triggers and plan to freeze if I see any risks or signs of OHSS. Even in the best of situations however OHSS can still happen. I believe the most important way to address OHSS is to have an open discussion about the signs and symptoms and make a plan with my patient about how to proceed. That being said, I do very few fresh transfers and have seen very few cases of severe OHSS since moving to that approach.
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