OK, Imran answered this question, but he’s currently restarting his computer, because Murphy’s Law… so from Imran:
In our early years we focused on using our approach to enable drug repurposing programs (“known compounds”), hence why 4 of our 5 clinical stage programs are with repurposed molecules. But for the last few years we’ve been using our maps to discover & optimize novel chemical entities, including both natural and synthetic ones - in fact our first new chemical entity (synthetic compound) just entered Phase 1 clinical trials!

For 2, see above!