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EmilyU1F984 t1_j7odx3x wrote

Reply to comment by ShakeNBakeGibson in We’re Recursion and we’re using AI to decode biology and industrialize drug discovery! by ShakeNBakeGibson

They didn’t stop the trials mate.

Viagra was brought to market first for Pulmobary Hypertension, and is still on the market for that indication.

After release reports showed massive benefit in ED, this approval for that second indication was obtained.

It is still the major treatment option for pulmonary hypertension an otherwise very quickly lethal disease and now progression can be delayed by decades at best.

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ShakeNBakeGibson OP t1_j7qcsog wrote

Please see the following paper with many helpful refs (https://www.nature.com/articles/nrd1468). Since it is behind a paywall, here's the relevant bit...

"Pfizer was seeking a drug for angina when it originally created sildenafil (Viagra) in the 1980s. As an inhibitor of phosphodiesterase-5 (PDE5), sildenafil was intended to relax coronary arteries and therefore allow greater coronary blood flow. The desired cardiovascular effects were not observed on the healthy volunteers tested at the Sandwich, England, R&D facility in 1991–1992. However, several volunteers reported in their questionnaires that they had had unusually strong and persistent erections. Pfizer researchers did not immediately realize that they had a blockbuster on their hands, but when a member of the team read a report that identified PDE5 as a key enzyme in the biochemical pathway mediating erections, a trial in impotent men was quickly set up. A large-scale study carried out on 3,700 men worldwide with erectile dysfunction between 1993 and 1995 confirmed that it was effective in 63% of men tested with the lowest dose level and in 82% of men tested with the highest dose. Of note, in many of these studies, Pfizer’s researchers had difficulties retrieving unused sample of the drug from many subjects in the experimental group as they did not want to give the pills back! By 2003, sildenafil had annual sales of US $1.88 billion and nearly 8 million men were taking sildenafil in the United States alone."

Sildenafil was approved for ED in the US in 1998, but was later approved for pulmonary hypertension in the US 2005.

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Trumpfreeaccount t1_j7q372i wrote

What a surprise a guy who's touting his ai based business is full of shit. Lol.

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JackIsBackWithCrack t1_j7qj9jz wrote

Settle down buddy

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Trumpfreeaccount t1_j7qkzq5 wrote

Pretty settled. Not sure why you're defending a guy who is just making stuff up in an AMA to make himself look knowledgeable. And using phrases like systemize serendipity.

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JackIsBackWithCrack t1_j7qwc6f wrote

Homie 99% of the posts on this god-forsaken subreddit are literally for the express purpose of free advertising. Claiming this guy is unknowledgeable solely because he is planning on using AI is both pointless and obtuse. Pointless because he’s probably just some PR intern and obtuse because AI has the potential to revolutionize the medical field (among others).

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