Yes take her to the vet to see if something is wrong.

Also make her a safe space in the house that's just hers where she won't be disturbed where it is quiet and safe cats like to go in spots that are enclosed (but can get out) where they feel hidden. They also feel safer with high perches.

Think about Maslows hierarchy of needs -are all of her needs being met? Remember that cats have stronger senses than people so a smell or sound that is tolerable to you might not be tolerable to her.

Good luck I hope your kitty feels better soon.

I can give more ideas but too tired right now so reply or message (not chat) if you want to brainstorm more