I do graphics, so I'm used to heavy key-chording.
Being able to switch from numbers to alphas to arrows and back, without moving your hand at all, is really nice.

I did a very intense study of exactly how I was using a keyboard in my work environment, then compacted that keyboard into a 60% footprint, designed for exactly how I work.

I'm working on the sister board to this, for home use.
That one's going to be a bit different because I don't game at work.
I'm putting that one into a 60% case as well, but will be using one without HHKB blockers.