I-81N to I-78E to PA 61N to PA 895E to PA 248N to US 209W(or S?) to PA 903N to PA 115N to I-80E. That's a VERY convoluted route but takes you thru some pretty nice Pocono's & farmstead scenery - the Schuylkill gap, parallel to the Blue Ridge on the north side, which is very rural, along the Lehigh River in a spectacular gorge, thru historic Jim Thorpe PA, up the Pocono's Escarpment, thru the Pocono's Plateau scrub brush forest country. You might hit tourist traffic around Jim Thorpe if you're traveling on a weekend, especially a big weekend like Easter, Memorial Day, 4th of July or Labor Day. This will also take SIGNIFICANT more time, although it's still generally in the same alignment as the major interstates. I grew up in Philly & my parents retired up that way in the late '70's ("Ashfield PA") so am fairly familiar with the area.