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nxtoth t1_j72el3h wrote

Reply to comment by Various-Program-950 in MDMA, psilocybin approved for psychiatric use in Australia by CouldDoWithaCoffee

doesn't mdma fry your serotonin generator? chimpanzee study? 10 years later still crappy even after 3 doses 3 months apart?

Edit: source: https://pubmed.ncbi.nlm.nih.gov/2575227/

Edit2: 2nd source: https://www.jneurosci.org/content/19/12/5096

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crisse-tabarnak t1_j72uwev wrote

injected 5 mg/kg twice daily ... that's kinda fucking insane dosage

also that study was retracted because they mixed up their vials ... what the actual fuck

author may have been politically motivated

yeahhhhhhhhhhhhhh

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Poschta t1_j738xvl wrote

Maybe to give some context, humans should do 1.5mg (male) and 1.3mg (female) per kg and 120mg at MOST with loooong breaks in between trips.

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WifoutTeef t1_j72kt6e wrote

No, not if you use it correctly in terms of dose and frequency

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NCSU_Trip_Whisperer t1_j72u9ga wrote

It can with frequent abuse, but I'm fairly confident one of those chimp studies was found to be using methamphetamine and not actual mdma

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KatiushK t1_j737y50 wrote

The dosage and is absolutely insane lmao

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ceruleanmoon7 t1_j738tqb wrote

I don’t trust that study, let’s just say I did a lot back in my day and I’m doing just fine.

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