Submitted by yeeturking t3_xx28my in askscience
[deleted] t1_irdhmvr wrote
Reply to comment by CocktailChemist in is it possible to synthesize proteins chemically? by yeeturking
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CocktailChemist t1_irdiys3 wrote
That is the essence of protection/deprotection chemistry. The peptide is generally attached to the resin using a functional group is is susceptible to the same cleavage conditions as the side chain protecting groups (HF for Boc peptides, TFA for Fmoc peptides) so that global deprotection and resin cleavage happen simultaneously.
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