> > > > > Finally, chromosomal structure and epigenetic modifications haven't been mentioned here. CRISPR/Cas9 gene editing doesn't provide the tools to restructure chromosomes, either in terms of the grouping of DNA into chromosomes or the packing of DNA into chromatin, nor does any other technology I'm aware of. I'm sure some researchers have been able to induce particular chromatin modifications, but much of how epigenetic regulation works remains unknown.

dCas9 (or other Cas proteins) can be fused to a variety of chromatin modifying factors, so epigenetic editing is entirely possible. But good luck doing that across the entire genome in a single cell.