itsybitsybiter t1_itt5q2t wrote on October 26, 2022 at 2:51 AM

For truly placebo controlled trials where standard of care is either absent or provided to both the test and control group, some studies will use a "crossover" design where participants who received placebo in the first phase of the trial will be offered the active drug in a second phase of the study. So all participants get the drug but the longitudinal data collection is the real test of efficacy (looking for inflections).

Please do be aware that Ivermectin has been reproducibly shown to have no effect against COVID 19 when put to well designed clinical trials.

Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19 A Randomized Clinical Trial. JAMA 2022
Effect of Early Treatment with Ivermectin among Patients with Covid-19 NEJM 2022

Nudelklone t1_itug5cu wrote on October 26, 2022 at 12:08 PM

A good example for those crossover design are the Covid vaccines. A friend of mine took place in the test of the vaccine. She was on the control group and was offered the vaccine after the end of the trial.