I would be very surprised if any creature resists chlorine trifluoride. That stuff will set materials such as concrete, sand, and asbestos on fire upon contact and reacts explosively with water. Teflon and some metals resist attack by ClF3, the metals by the formation of a surface metal fluoride layer, and neither are found in known lifeforms to my knowledge.

Dioxygen difluoride is also up there. It's nicknamed "FOOF" for a reason, blowing up on contact with solid ethanol, liquid methane, and water ice to name a few.

There are acidophile and alkaliphile organisms, but I suspect superacids would destroy all known life too.

https://www.science.org/content/blog-post/sand-won-t-save-you-time

https://www.science.org/content/blog-post/things-i-won-t-work-dioxygen-difluoride

Outside the realm of chemistry a high enough temperature, intense enough ionising radiation, or extremely strong magnetic fields will destroy all known molecules whether living or not. (In the magnetic field case, this is way beyond anything we can produce on Earth, but neutron stars will do it.)