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cristiano-potato t1_ivgil3k wrote

Reply to comment by Laawlly in We know about viruses, bacteria and other microorganisms evolving to better infect other organisms. Consequently, diseases change too to some extent. Are there any examples of human bodies evolving to fight against these disease causing agents? by ha_ha_ha_ha_hah

Yeah I don’t see how NK cells would recognize Covid virons directly, I did mean recognizing the infection by way of recognizing infected cells that are stressed.

I will paste the study I found prior when I am able to find it again, when I’m off mobile. I did find this one: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909049/

Which talks about the studies examining the effects of exercise on NK cells, some studies report conflicting results but it seems this is often due to exercise dose.

I also wonder about things that are fairly common and usually benign like SIgAD, or far more commonly partial IgA deficiency (PIgAD). I found one study that found a 4x odds ratio for severe Covid in SIgAD patients, but the CIs are massive, this doesn’t apply to PIgAD (generally defined as IgA levels below 2SD of the median but not below detection limits, for example if reference range bottoms out at 90mg/dL and you find 30, that’s not <5 but it’s low), and also you have the bias inherent in the fact that many SIgAD people are asymptomatic so a cohort of diagnosed SIgAD people is going to probably include mostly symptomatic cases since they’re more likely to be detected.

But PIgAD is far more common, obviously simple math dictates a low single digit or slightly below 1% rate. If this is associated wifi more severe Covid outcomes I’d wonder what can be done for those patients since IgA deficiencies can’t really be “treated” effectively and even a mucosal / nasal vaccine would not help much if their B cells are being arrested before maturing to the point of creating IgA antibodies

Thanks for the explanation w.r.t. CD56.. I wonder what the most crucial element in the naive host is? Innate immunity wise. IgA? Can that be created quickly even if you’re immune naive? Thinking about back in 2020 how some immune naive hosts still had mild course. Or is it just that their innate immune system reacted quickly? Given the high concentration and extensive proliferation of neutrophils, they’d probably be the first to come across the infection and sound alarm bells no?

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