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TaiCookie t1_ivp3xvi wrote

Your body doesn't. It's more microaganisms stay in their place, and don't travel to areas that can harm you. Bacteria on your skin is natural but is opportunistic ,if it enters a cut for example, it can cause infection. Even healthy gut bacteria are separated from your tissue via mucus layers.

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askoemnzviwcasf t1_ivpbyev wrote

Yes and no, separation is an important part of keeping microbes out of areas where they can cause damage however the immune system regulates all microbes to some extent and recognizes them based on a variety of factors but some have a privileged status. This isn't really my area but commensal microbes engage in crosstalk with the immune system which is necessary for long term colonization.

Here's an article with more information: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109969/

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