Hello. Gastroenterologist here. As with all health questions, the answer is nuanced and complicated. I’ll highlight a few relevant points here that I didn’t see addressed in some of the other responses.

1. The digestion process is multistep and the stomach involvement is one of the earlier steps. Most of the absorptive surface area is in the small intestines. The stomach provides mechanical mixing in an acidic environment in addition to the mechanical breakdown started by the chewing process in some of the digestive enzymes found in saliva. Other key enzymes, including those made by the exocrine pancreas are mixed with the food stuffs starting in the second portion of the duodenum via biliary system through bile excretion.

2. the stomach is sensitive to vascular considerations similar to all tissues in the body. The minimal amount of blood delivery for oxygenation and energy delivery for a tissue to function will vary depending on the tissue. The cardiac output necessary for functions at rest are generally much lower than the maximum cardiac output that the heart can achieve. While cases of insufficient blood delivery to the G.I. tract can occur, this would be unusual to come from just the medications mentioned here at intended doses unless there were some other extenuating circumstance. Gut ischemia can occur with severe disruption of blood flow such as vascular blockage of specific systems (such as a clot) or global hypoperfusion from significant decreases in cardiac output, like that found in shock physiology.

Please excuse any typos as this response was done on my phone via voice recognition.