Submitted by itsabenhere t3_yw939i in askscience
iayork t1_iwkrllh wrote
Reply to comment by rhowsnc in Why do T cells need to bind self-antigen moderately? by itsabenhere
Depends what he’s calling “this scenario”. OP is specifically asking about developing T cells in the thymus. Those do occasionally bind with high affinity to the MHC/self peptide combination in the thymus, and those T cells are destroyed - it’s a normal part of T cell development, aimed at preventing autoimmunity (because if those T cells were allowed to survive and become mature, functional T cells, they could indeed cause autoimmunity - though there are further checks and balances even there).
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