Submitted by arlomurfett t3_z1fohw in askscience
The-very-naughtyduck t1_ixc39wm wrote
In addition to the other answers, antigen naive (i.e. never-before activated) B and T cells circulate constantly between lymph nodes and blood. This maximises the chances of B and T cells finding their antigen and responding, even if the antigen is only found in those lymph nodes nearest to the infection.
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