Viewing a single comment thread. View all comments

[deleted] t1_j22z35d wrote

Reply to comment by kruel1 in In Parkinson disease, why doesn't the adrenal gland fill the dopamine deficiency? by Actual-Pumpkin1567

This is very well written.

I'd add that levodopa gets converted to dopamine by decarboxylation, but to ensure this only happens in the brain (where it is actually required) and not in the rest of the body (since a dopamine overdose would not be in our interests) we use carbidopas which are peripheral DOPA decarboxylase inhibitors (DDCI)

68

CaptainDadJoke t1_j22zx43 wrote

see, this is why I tell people they're wrong when they call me smart. I understood maybe a quarter of all of this :D You beautiful amazing people are awesome, I love seeing someone talking shop about their craft like this. Keep up the good work and I thank you all for this I now have lots of things to google while I'm stuck here at work.

26

defaltusr t1_j23qq90 wrote

Lol, I just commented the exact same. Black holes, james web telescope, how stuff behaves at close to lightspeed, no problem. But no idea what these people are talking about

8

Fellainis_Elbows t1_j23rzhz wrote

We add an extra medicine to block an enzyme that would convert the medication we want to be converted in the brain too early, out in the peripheries.

11

HayzenDraay t1_j24a74d wrote

Mmmm, yes, decarboxylation, I'm definitely familiar with this term for legitimate reasons.

23