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bicbrownboi t1_j5ix3ue wrote

Turnover rate is relevant for neurotransmitters which are degraded within the synapse. Some NTs are not (see serotonin- not degraded within the synapse to a significant degree, mostly reuptaken by the presynaptic side). Acetylcholine on the other hand is degraded by acetylcholinesterase within the synapse, and its components are then reuptaken. Turnover rate refers to the degradation rate (basically the amount of acetylcholinesterase in the synapse)

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Felted_Grape t1_j5ixn5o wrote

Interesting. From the name I would have assumed it was the rate of production of acetylcholine in the presynaptic cell. Thanks for the answer

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Devil_May_Kare t1_j5ixx1t wrote

Sarin gas works by breaking acetylcholinesterase. That reduces the turnover rate of acetylcholine. Maybe OP was reading about sarin?

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daywalkker t1_j5jkb6v wrote

Not just Sarin, any organophosphate can hamper the ACh turnover rate. Remember the signs of organophosphate toxicity: SLUDGE

Salivation

Lacrimation

Urination

Defecation

Gastroenteric problems

Emesis

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Bax_Cadarn t1_j5jl8ku wrote

I have a question: how do Americans always have acronyms for everything? I try to do that in Polish and all I could figure out was causes of acute pancreatitis.

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BirdLawyerPerson t1_j5jqppg wrote

Any acronym related to illness, disease, or medical issues, I just assume come from medical students trying to cram for exams. The sheer amount of lists they have to memorize makes acronyms a pretty good memorization technique.

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Citrownklown t1_j5j2wpc wrote

Good point.

AcCh turnover increase means more is degraded by the enzyme, decrease the opposite.

Depending on the location of the turnover (central nervous system or e.g. In skeletal muscles) this could lead to prolonged or shorter duration of AcCh.

One cool example of a drug working by decreasing AcCh effect (ultimately) is botox, leading to temperary paralysis on the injection site.

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curiousnboredd t1_j5k3zku wrote

iirc Botox causes muscle relaxation (opposite to tetanus which cause contraction) so wouldn’t that mean it causes a decrease in acetylcholine and increase in acetylcholiesterase?

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Citrownklown t1_j5kdjzt wrote

It looks like the mode of action of botox is a bit more complex (here’s from one of my favorite webpages drugs@fda)

12.1 Mechanism of Action BOTOX blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings. When injected intramuscularly at therapeutic doses, BOTOX produces partial chemical denervation of the muscle resulting in a localized reduction in muscle activity. In addition, the muscle may atrophy, axonal sprouting may occur, and extrajunctional acetylcholine receptors may develop. There is evidence that reinnervation of the muscle may occur, thus slowly reversing muscle denervation produced by BOTOX.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103000s5236lbl.pdf#page13

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Fantastic-Arrival556 t1_j5uxgry wrote

Are new neurotransmittors created often? From the food we eat for example. Or is most of it recycled materials our brain just keeps reusing?

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