What will follow is a a series of oversimplification, but I hope that it will help.

Consider the main philosophical question in the Ancient Greek people, often considered to be the source of philosophy in the Western world; "What is happiness?" and "How can we be happy?"

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Consider the main philosophical question of metaphysics, "Is there a God?", and "if there is, what is our relationship to God?"

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Such simplifications can be made for epistemeology (What is knowledge? Can we know anytyig? What does this mean for us?), or for the political philosophy that was so popular during the Renaissance and well into the 20th century.

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Nietzsche is arguably in different in not asking what X means for human beings in the context of philosophy, but what human beings means, and what being a human being entails in the context of philosophy.

Nietzsche is the first one to situate philosophy in our daily life, and in our existence in general. The first one to ask, "How one must live?" or "what is the proper way to live?" in that, he is the one questioning what is the proper way to exist, as opposed to discussing how a particular wary of existing might benefit us

I suggest Camus' "The Myth of Sisyphus and Other Writings" by Penguin for a more eloquent and detailed explanation.