From Albany, NY, take I-87N until it intersects with Route 9N, and travel west on 9N. This intersects Route 73, which takes you west to North Elba, and on to Lake Placid. This intersects Route 86, turn right onto 86.

The drive from there to Wilmington is, the most natural beauty I have ever seen. There will be a long creek on your left, and mountains and cliffs all around you. If it's in season, you can drive up to the top of Whiteface Mountain (bring a jacket!), where you'll be able to see the foliage for miles and miles. You're in the Adirondack Mountains, so there's all sorts of natural beauty around you.

The town of Lake Placid is where I'd like to retire someday. Beautiful area.