NSAIDs do not target inflammation. They are delivered systemically and bind to certain molecules present in enzymes that are more abundant at the site of inflammation, inhibiting further production of prostaglandins and reducing inflammation.

In other words, it is more of a passive effect from systemic delivery, but it is not targeting. “Targeting” would imply that the medicine is taken and then goes to a specific location to create an effect; that is not what is happening here.

Even with localized delivery (e.g. steroidal anti-inflammatories), it’s more that a higher concentration is being delivered to the site and directly passing/binding whichever receptor it’s designed for, rather than wandering around until it finds what it needs, so to speak.