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OrbitalATK t1_iu73zij wrote

No shocker since most vaccines target the spike protein, there are more mutations in the spike protein to get around the protection offered from the vaccines.

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WSL_subreddit_mod t1_iu896j5 wrote

I've seen no indication of significant mutation in the protein spike.

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OrbitalATK t1_iu8fj50 wrote

Take a look at the original SARS-CoV-2 and the Omicron variant, where are most of the mutations?

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WSL_subreddit_mod t1_iu8j3u1 wrote

The current mutations are derived from and still considered to be the Omicron variant.

I guess the issue I took with your comment was that you made it under an article about the current mutations, and that is the context under which it is read.

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OrbitalATK t1_iu8u5hp wrote

Even comparing Omicron (BA.5) to the current variants (BQ.1 and BQ.1.1), where are the mutations occurring?

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OrbitalATK t1_iub0shj wrote

I guess I'll answer it, and not surprisingly, the answer is the spike protein. I wonder why.

> BQ.1* is a sublineage of BA.5, which carries spike mutations in some key antigenic sites, including K444T and N460K. In addition to these mutations, the sublineage BQ.1.1 carries an additional spike mutation in a key antigenic site (i.e. R346T).

https://www.who.int/news/item/27-10-2022-tag-ve-statement-on-omicron-sublineages-bq.1-and-xbb

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