Realtor here! Many of my buyers from elsewhere (with families) who want some type of suburban/urban hybrid land on Manayunk/Mt. Airy/East Falls. Good local stuff to walk to, tree-lined streets, hopefully a driveway/garage. More space and quiet than most Philly neighborhoods.

Roxborough and the Far Northeast I wouldn't necessarily recommend (your safety concerns aside). They are just a bit too culture-less feeling for most folks. Think more chain stores, less corner businesses to enjoy, and lack of public transit.

There are great suburbs to consider, too! But first, I'd decide if you want Philly proper.