It really depends what your priorities are. Every neighborhood has pros and cons.

Fox Point is the most well rounded neighborhood in my opinion: walkable, nice architecture and curb appeal, good shops, diverse population.

Hope has the best most neighborhoody Main Street.

College Hill has great architecture but it’s only main drag (Thayer) is basically a student ghetto, so it’s really not that walkable.

Mount Hope has nice architecture and is a short drive to a lot of places but isn’t that walkable.

Wayland has great architecture, nice parks, and a nice main square, but is sleepy and boring (great for families but maybe not for non-families).

Federal Hill/West End have great night life and are walkable but can be less attractive blocks than the east side and not much green space. The exception is the area around the armory which is a fantastic community and pretty pocket though hemmed in by highways and the hood.

Downtown is actually a great place to live without kids. Walkable, great architecture, a lot going on.