I work from home and rarely drive. Mass transit is a bit of the pain unless you're taking the Pulse, but the city is fairly bike-friendly. Actual bike infrastructure is a bit sparse, but the city itself is pretty doable by bike.

There will be parts of the city that will be rather inaccessible (getting to a Trader Joe's will be a hike) but if you're comfortable with urban biking and the risks that entails, it's doable.