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dreamlike_poo t1_j7wd5qf wrote

Reply to comment by MushroomNovaCat in Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (Feb 2023) by basmwklz

The scientific community has known for decades that calorie restriction increases longevity in mammals, but the exact mechanisms weren't well understood. It seems like we might be narrowing down the way it works.

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MushroomNovaCat t1_j7x2276 wrote

Yes, we know caloric restriction works, my point wasn't to point out that it doesn't work, my point was to point out that we don't know that it leads to better health because of the lower caloric intake or because of other associated factors as was profusely discussed in the study you linked.

Your second link discussed research suggesting that when we eat is important as well, which we have also known for a while, but this has nothing to do with determining the reason why caloric restriction leads to better health and longevity. We still don't know if it's the associated factors that are responsible rather than the lower intake of calories itself.

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