It's worth saying that this is true of almost all food. There are tons of essential nutrients that you basically can't absorb or use without gut bacteria, which is why microbiomes are so important for digestive health.

The fact that fructose has to be broken down first (in the liver) is essentially trivia (and information about what you can eat after antibiotics/surgery) rather than some deep statement about what is "natural" for humans to consume (which I think is what the comment you responded to was implying).

Edit: I think fructose is actually broken down in the liver, not the digestive tract. The point still stands though: the digestive system is complex, and the chain being more than one step long is normal.