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Darkhorseman81 t1_j9swtfp wrote

Reply to comment by hippydog2 in Researchers have found that a Parkinson’s-linked mutation in a gene called Endophilin A1 blocks the process by which the body and the brain recycle cell waste. Without the process, autophagy, toxic debris builds up and neurons die. This discovery could change the focus of Parkinson's treatments. by QldBrainInst

Excess S-Nitrosylation blocks it's function in most cases. Mutation would be a rare exception.

We've know this for a while, but they have just shown an extra mechanism by which it happens.

It's why nitrogen pollution from exhaust fumes is linked to parkinsons.

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accidental_snot t1_j9vf290 wrote

The earth's atmosphere is 80% nitrogen. What does it matter if it's in exhaust? Bonded with something to make some toxic molecule?

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Apprehensive_Ad1744 t1_j9vpujw wrote

Atmospheric nitrogen just nitrogen, N2, which is relatively inert.

Nitrogen in exhaust are nitrogen oxides, namely NO and NO2, which are quite toxic.

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