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Rain_Dont_Pour OP t1_jb50wox wrote

https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2254/716616/Quiescent-ovarian-cancer-cells-secrete-follistatin?redirectedFrom=fulltext

DOI: https://doi.org/10.1158/1078-0432.CCR-22-2254

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damnan99 t1_jb52qh2 wrote

So you would have to reduce the production of follistatin to reduce the chemo resistance?

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Rain_Dont_Pour OP t1_jb61qjr wrote

I believe what they're trying to say is that you would have to create an antibody that would block the action of follistatin so it doesn't bind to the receptor. I think the concept of lowering the levels of follistatin is not feasible, but it could be a possibility that the authors haven't looked into.

From my understanding, they were able to create cells that didn't produce follistatin and that's how they proved that absence of it made ovarian cancer cells more sensitive to chemo.

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