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flaminate_strutching t1_jbv7l7s wrote

Reply to comment by tyler1128 in MDMA appears to confer resilience in a rodent model of chronic social defeat stress by chrisdh79

Do you have any links to the studies that found a connection between serotonin and depression? Or that demonstrate long-term improvement in quality life with SSRIs?

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Timely-Huckleberry73 t1_jbvgzht wrote

As far as I know all studies (certainly most studies) that have found antidepressants as “effective treatments” for depression are much shorter than the durations for which antidepressants are typically prescribed. Most studies last a few months at most. The evidence for long term effectiveness is lacking, however, there is certainly evidence of long term harm.

https://pubmed.ncbi.nlm.nih.gov/21459521/

Unfortunately there is insufficient data on long term outcomes because such studies would be expensive to conduct and the results of such studies would almost certainly be harmful to the extremely lucrative sales of antidepressants.

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