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1

Reggie__Ledoux t1_it022me wrote

> Abstract

> Cannabidiol (CBD) has emerged as a phytocannabinoid with various beneficial effects for the skin, including anti-photoaging effects, but its mechanisms of action are not fully elucidated. The study assessed CBD's photoprotective effects against acute ultraviolet B (UVB)-induced damage in HaCaT human keratinocyte cells and murine skin tissue. CBD (8 μM) alleviated UVB-induced cytotoxicity, apoptosis, and G2/M cell cycle arrest in HaCaT cells. The contents of γH2AX and cyclobutane pyrimidine dimers were decreased after CBD treatment. CBD reduced the production of reactive oxygen species and modulated the expression of antioxidant-related proteins such as nuclear factor erythroid 2-related factor 2 in UVB-stimulated HaCaT cells. Furthermore, CBD mitigated the UVB-induced cytotoxicity by activating autophagy. In addition, a cream containing 5% CBD showed effectiveness against UVB-induced photodamage in a murine model. The CBD cream improved the skin's condition by lowering the photodamage scores, reducing abnormal skin proliferation, and decreasing expression of the inflammation-related protein cyclooxygenase-2 in UVB-irradiated skin tissue. These findings indicate that CBD might be beneficial in alleviating UVB-induced skin damage in humans. The photoprotective effects of CBD might be attributed to its modulatory effects on redox homeostasis and autophagy.

https://pubmed.ncbi.nlm.nih.gov/36235276/

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har3krishna t1_it03n9u wrote

Isn't this how Rick Simpson oil got famous?

6

rouxmama t1_it0fia4 wrote

Replying to [deleted] (#147,678)

Did you read the first line of the article? They have found it DOES help with the effects of photo-aging of skin, they just don’t understand HOW it works yet.

−1

Ecnassianer t1_it0il1o wrote

It was not clear to me from the article, did they study applying topical CBD before sun exposure (i.e, as sunscreen) or after sun damage (i.e, burn salve). Does anyone else know which it was?

62

tagh-beatha t1_it0jvi8 wrote

Replying to Ecnassianer (#149,142)

“The CBD cream improved the skin's condition by lowering the photodamage scores, reducing abnormal skin proliferation, and decreasing expression of the inflammation-related protein cyclooxygenase-2 in UVB-irradiated skin tissue. These findings indicate that CBD might be beneficial in alleviating UVB-induced skin damage in humans. The photoprotective effects of CBD might be attributed to its modulatory effects on redox homeostasis and autophagy.”

I’m copying this from another comment that copied the abstract of the article. You have a really good question, I wasn’t sure either but after reading this I think the CBD cream was used like an after sun.

63

bananahammerredoux t1_it0vwwj wrote

Is anybody else getting tired of reading headline after headline about how cannabis does aaaaaall the things like it’s some magical freaking cure-all? No? Just me?

11

ThePharmercy t1_it15nyv wrote

Cannabis studies are like the new “left handed people actually do (x) better” studies

10

Enorats t1_it19a4c wrote

Replying to bananahammerredoux (#149,995)

It's annoying, but the internet seems to have been taken over by potheads these days. Anything containing the words CBD, cannabis, hemp, or the number 420 is just inexplicably fawned over.

−7

sri_vidya t1_it1bhzw wrote

Replying to [deleted] (#147,678)

The study was done in mice so that isn't enough evidence to say it will hold true in humans. And even when they do a study in humans, you need a lot of them (humans and studies) to be conclusive

3

supagirl277 t1_it1goha wrote

So… it helps with sunburns basically

1

Law_Doge t1_it1rz0p wrote

You gotta use the UVB to grow the CBD to combat the UVB. Wild

1

Redz0ne t1_it1yh4m wrote

Replying to tagh-beatha (#149,227)

Sunscreen with CBD seems like it'd be a home-run product for people that are on the CBD bandwagon.

Though CBD lotions are pretty good for just general lotion uses anyway (as long as the lotion is good quality and isn't greasy.)

17

ubermeisters t1_it37un6 wrote

I'm all about positive reports from scientific studies on marijuana, as a casual pot user...

But this source doesn't seem like the highest quality source we could be finding for something of this nature..

2

Aboxofphotons t1_it3bvvl wrote

Any title of an articale which contains the word "might" in this context should be ignored.

2

Krispy337 t1_it3pco7 wrote

Rick simpson been knowing this

1

Override9636 t1_it3tf4o wrote

Replying to Traumfahrer (#152,587)

*In mice, with sample sizes ranging from 5-10 among 6 different studies.

While interesting, it definitely warrants much more data, with larger human trials before a strong correlation can be stated.

2

Socky_McPuppet t1_it3w3lu wrote

Replying to tagh-beatha (#149,227)

That would be what I would assume from the word "alleviating", rather than, say, mitigating or preventing. But it's pretty bad that the wording is so unclear that the question has to be asked. That seems like a pretty basic thing to want to know.

2

Traumfahrer t1_it3xplk wrote

Replying to Override9636 (#156,390)

> While interesting, it definitely warrants must more data, with larger human trials before a strong correlation can be stated.

Definitely, but that's why I said the above. I've seen it mentioned here and there over the years. That study with the first google result btw.. At least it seems promising.

1