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a_stoic_sage t1_iv6hp67 wrote

Reply to comment by WilyStylyMethody in BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa

Can't placebo effect rewire or repair certain neural pathways? If you think you are feeling better, you are rewiring your brain?

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westderecho t1_iv76y9b wrote

SSRIs exert a neurogenic effect on the hippocampus and increase the amount of neurotrophic factors there, and also alter the count/ratio of certain serotonin receptors.

To my knowledge this behavior isn't readily found in placebo trials when comparing against SSRIs, and a placebo would not be able to target a certain region.

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WilyStylyMethody t1_iv6js8e wrote

That I'm not sure of. Hopefully someone more knowledgeable can chip in here.

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