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charliedontplaydat t1_iv6iqlk wrote

Reply to comment by doctoreldritch in BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa

SSRI’s are so hit and miss because of the event observes for this study. If one doesn’t produce or release seratonin, there isn’t a point in making the nonexistent molecules float around longer before being reuptaken.

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westderecho t1_iv75d8g wrote

Serotonin releasing agents(or rather tri-amine releasing agents) were some of the first antidepressants ever made, and were extremely successful. Consequently they had some severe side effects, and also sometimes worked "too well"(causing euphoria) so they had a short lived existence.

Example being a-met

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