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eng050599 t1_ixy8r6o wrote

...even the IARC rejected the Seralini paper, and for the exact same reasons why it was retracted in the first place.

From the IARC Monograph:

The Working Group concluded that this study conducted on a glyphosate-based formu-lation was inadequate for evaluation because the number of animals per group was small, the histopathological description of tumours was poor, and incidences of tumours for individual animals were not provided.

As for Mesnage and Antoniou, the main issue with them is that:

a) They haven't conducted any OECD compliant study, and instead make use of weaker, correlative studies.

b) They explicitly go against the recommendations relating to large scale 'omics analyses in toxicology.

One of the results of the whole Seralini lumpy rat study, was the EU commissioning 3 different studies (GRACE, G-TwYST, and GMO90+) to determine if there was any validity to the conclusions of Seralini et al., (2012).

The GRACE project specifically examined the effectiveness of molecular fishing studies conducted on transcriptome and proteome-level analyses.

The results were not surprising, as they found that the level of Type I errors was too high for them to be used directly to conclude even correlative effects. The reason for this is that these studies typically involve far more pairwise comparisons than even our best ability to correct for multiple comparisons can handle...a problem that we in the research community deal with frequently.

Studies of this type should only be used to identify prospective targets for further examination using specific testable hypotheses.

To the surprise of none, neither Antoniou, nor Mesnage have performed such follow up work in relation to their transcriptome screenings.

Yet again, you seem to be a bit lacking when it comes to knowledge relating to these topics.

Fortunately, I do not suffer from such an handicap.

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