Yes, but hitting that end of the spectrum is something that only a very small portion of people will do, and even those negative health outcomes are minor compared to those from living a sedentary lifestyle. Unless you're training for extreme distances, there's practically only benefits for aerobic exercise.

That’s a really interesting article. Thanks for posting it.

Good point. We have a tendency to believe that if some is good, more must be better, but the body (and biological systems in general) often do not work that way.

There's often a dose-dependent response, where a low level (or zero) is harmful/deficient, some moderate value is increasingly optimal until a point is reached where additional produces no effect and eventually becomes harmful.

A lot of people who live to be 100 merely had active lifestyles, but weren't athletes or preoccupied with fitness.