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A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism

If NAD+ status is improved systemically and produces an antiaging effect on the metabolism and brain, it ought to enhance inclination towards aerobic exercise. This isn't far-fetched as oxidative stress and energy status in neurons in the nucleus accumbens and pons at the top of the spinal cord mediate perceptions of pain and thereby inclination to move, as well as the reward circuitry of the brain. This is why analysis of specific systems can lead to conclusions that may be wrong because these things aren't happening just to the particular thing examined. Such a large protective effect from aerobic exercise may in theory eliminate any risks overall in the case of the claimed risk of nicotinamide riboside. It might also not show up in all cancer types.

We do know that metabolic nutrient cocktails, such as R-Lipoic Acid and AL-Car, PQQ, have rejuvinating effects in aged animals , and that was observed by the researchers to be reflected in increased movement and more youthful behaviours.