>To date, over 620 million people have been infected by SARS-CoV-2 with a significant proportion of them infected during the Omicron wave. While most patients survived the infection, post-COVID-19 sequela including neurological manifestations are common.10 The increased efficiency of BA.2 to replicate and causing apoptosis in the brain organoids is alarming, indicating that the long-term consequence of BA.2 infection in the CNS should be closely monitored.