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aleph32 t1_iwnobfc wrote

This was a negative result for what they set out to show.

As for dosing: > Each cannabis dose consisted of 10 mg of THC (two standard THC units [16]) and either 0 mg, 10 mg, 20 mg, or 30 mg of CBD. Participants were given preparations with CBD:THC ratios of 0:1, 1:1, 2:1, and 3:1, in a random order across visits.... Cannabis preparations were administered using a Volcano® Medic Vaporiser

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charmorris4236 t1_iwnqnf1 wrote

Sheesh were these people extremely heavy smokers because I puked the first time I tried a volcano and I smoked pretty often

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tofu_schmo t1_iwo34bf wrote

They have tiny caps you can fill and place in the bowl to make the hits much less intense. I can't imagine taking medicinal amounts of weed through a volcano with a full size bowl!

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charmorris4236 t1_iwo4qkc wrote

Ahh okay that makes more sense. To me volcano = stupid high, even with a tolerance!

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BrothelWaffles t1_iwo3kdc wrote

10mg is a seriously light dose for smoking / vaping. It's like, 1/20th of a gram of 20% THC bud, which is on the lower end of potency these days. For reference I'm not a super heavy smoker but I do have a bit of a tolerance, and I use a Dynavap with about 1/8th of a gram per session, 4 - 6 times per day. Depending on the strain that's anywhere from 25 to 40 mg per session.

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realJanetSnakehole t1_iwouenp wrote

Isn't 10mg what's usually in gummy edibles? When I first started taking edibles recreationally I had to split them into 8ths, and even then it was almost too strong of a high for me.

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Geo_Doug t1_iwpqj2s wrote

My understanding is that potency from edibles doesn’t track super well to inhaled products. That said, response is subjective for each.

Regardless, I personally agree with the original comment - these doses may be too low to illicit strong enough responses to either THC or CBD.

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thalassicus t1_iwtndvs wrote

You’re correct and the poster above stating 10mg is no big deal is incorrect. The actual percentages of bioavailability varies with a bunch of factors, but is highest via inhalation (31%-50%) followed by sublingual. Ingesting is pretty inefficient (10%-19%).

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