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True_Garen OP t1_iy0zt55 wrote

Reply to comment by Efficient_Lecture_98 in Obesity Is Now the Top Modifiable Dementia Risk Factor in the US (July 2022) by True_Garen

I'll mention here that while this study puts smoking as a risk factor, it has been long observed that smokers have relative immunity to AD. Nicotine is neuroprotective, and lowers the risk of AD by more than half.

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SerialStateLineXer t1_iy1xqmv wrote

Evidence on this is mixed at best. While there is some evidence for a neuroprotective effect of nicotine, this appears to be offset by the negative cardiovascular effects of smoke inhalation. Even nicotine itself has a vasoconstrictive effect that could offset the neuroprotective effects seen in vitro.

Smoking does seem to be protective against Parkinson's Disease in particular, though.

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True_Garen OP t1_iy21qb7 wrote

>neuroprotective effects seen
>
>in vitro

We see the benefits for memory in vivo with our own eyes...

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