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AnthemWild t1_ix2nowi wrote

What does this mean in layman's terms?

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Mountain-Rush-1744 t1_ix2oiat wrote

Being cold burns fat

Edit: check out the book "what doesn't kill us", for a better explanation and deep dive

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basmwklz OP t1_ix2ls51 wrote

Summary

Background

The application of cold exposure has emerged as an approach to enhance whole-body lipid catabolism. The global effect of cold exposure on the lipidome in humans has been reported with mixed results depending on intensity and duration of cold.

Methods

This secondary study was based on data from a previous randomized cross-over trial (ClinicalTrials.gov ID: NCT03012113). We performed sequential lipidomic profiling in serum during 120 min cold exposure of human volunteers. Next, the intracellular lipolysis was blocked in mice (eighteen 10-week-old male wild-type mice C57BL/6J) using a small-molecule inhibitor of adipose triglyceride lipase (ATGL; Atglistatin), and mice were exposed to cold for a similar duration. The quantitative lipidomic profiling was assessed in-depth using the Lipidyzer platform.

Findings

In humans, cold exposure gradually increased circulating free fatty acids reaching a maximum at 60 min, and transiently decreased total triacylglycerols (TAGs) only at 30 min. A broad range of TAG species was initially decreased, in particular unsaturated and polyunsaturated TAG species with ≤5 double bonds, while after 120 min a significant increase was observed for polyunsaturated TAG species with ≥6 double bonds in humans. The mechanistic study in mice revealed that the cold-induced increase in polyunsaturated TAGs was largely prevented by blocking adipose triglyceride lipase.

Interpretation

We interpret these findings as that cold exposure feeds thermogenic tissues with TAG-derived fatty acids for combustion, resulting in a decrease of circulating TAG species, followed by increased hepatic production of polyunsaturated TAG species induced by liberation of free fatty acids stemming from adipose tissue.

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Partucero69 t1_ix2u4aa wrote

So If you’re exposed to the cold properly geared to don’t frostbite your skin. and do workouts cardio etc outside does it helps to burn fat as twice as normal either exposure to the cold or just do workouts inside the gym? Asking because that’s something I always want to find out.

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ButterflyCatastrophe t1_ix33o7h wrote

This study was designed to maximize non-shivering thermogenesis, and any muscular activity is going to be a source of heat that reduces the drive for non-shivering thermogenesis. i.e.: you need to feel uncomfortably cold.

They couldn't/didn't bother to tell us what temperature they used, but their subjects were all lying in chilled water baths, adjusted to just above uncontrollable shivering. That probably means a core body temperature around 35 oC.

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Bikrdude t1_ix3mh0l wrote

If they didn't provide the temperature the work is not high quality

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ButterflyCatastrophe t1_ix43151 wrote

Eh. They chilled everyone until they started shivering, then warmed them until they stopped. Temps are going to depend on individual body shape, fat distribution, and who knows what else. I can see an argument where the average wouldn't be particularly informative, and might be easily misinterpreted as a special bathing temperature that triggers TG release. It'd be nice to know; it'd be nice to have core temperature records; but there's always improvements to offer after the fact.

"Not high quality" is undeserved.

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FailOsprey t1_ix46lzy wrote

What your saying makes sense. From an ethical standpoint, shivering seems like a safe gauge of when to heat up the water. It takes away the ability to control the water temperature, which is bad, but it reduces the likelihood of lawsuits and harm.

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Mountain-Rush-1744 t1_ix2x0g4 wrote

Look up Wim Hoff

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Kidogo80 t1_ixdmqbr wrote

I keep thinking to dive into my pool in the winter but I always whimp out (and its not that cold in Phoenix).

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beachling2 t1_ix2qg1b wrote

Hey! I couldn’t quite understand the article. Does cold exposure mean being cold or like being properly bundled in cold weather?

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